在怀孕期间,人类尿液中雌激素和孕代谢物的动态变化
Chen Jin1, Ying Peng2, Xiaoyan Luo2
1Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, Guangdong, China.
Scientific reports
|March 12, 2025
概括
这项研究跟踪了整个怀孕期间的雌激素和孕代谢产物. 尿液水平显示出不同激素的不同模式,有助于怀孕监测和并发症诊断.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 雌激素和孕激素代谢产物对于正常怀孕至关重要.
- 这些代谢物在整个妊娠期间的动态变化尚未完全理解.
研究的目的:
- 在正常怀孕期间,系统地测量人类尿液中雌激素,孕激素及其代谢物的时间变化.
- 为了提供荷尔蒙代谢物在妊娠期间的激素代谢物动态的全面概况.
主要方法:
- 超高性能液体染色学-并联质谱学 (UPLC-MS/MS) 用于精确的量化.
- 在整个妊娠期内收集人体尿液样本.
主要成果:
- 在怀孕期间,雌激素,雌醇和雌醇水平逐渐增加.
- 某些基化和甲基化代谢物表现出不同的时间模式,一些早期减少,另一些在怀孕中期达到峰值,一些在整个怀孕期间增加.
- 孕激素及其代谢物在怀孕中期呈现增加,随后在怀孕后期呈现下降.
结论:
- 这项研究提供了妊娠期间尿液中雌激素和孕代谢物的综合动态概况.
- 这些发现可以支持激素监测,怀孕并发症的早期诊断和机械学研究.
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