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Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

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Updated: May 23, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

使用对左心室功能无监督集群分析进行过多心肌病的补充分类.

Dandan Sun^1,2, Xingyu Fang^1,2, Yuzhu Zhang^1,2

¹Department of Ultrasound, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, 110067, China.

Scientific reports

|March 12, 2025

概括

研究人员根据左心室功能确定了两种超性心肌病 (HCM) 亚型. 亚型1 HCM 患者表现出功能障碍和较高的心房动风险,有助于个性化治疗多变性心肌病.

关键词:

心房动是一种心房动.集群分析就是对集群进行分析.过度缩性心肌病变性是一种心脏病变.多维回声心脏学参数的多维回声心脏学参数

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Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

相关实验视频

Last Updated: May 23, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

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Published on: April 21, 2014

科学领域:

心脏病学心脏病学
生物医学工程生物医学工程
医疗成像医学成像

背景情况:

目前的高缩性心肌病 (HCM) 分类依赖于高缩部位和流出管道阻塞.
功能分类可以改善HCM患者的风险分层和风险管理.

研究的目的:

根据左心室 (LV) 功能的基础上,开发一项对缩性心肌病 (HCM) 的补充分类.
识别具有不同心血管风险的独特HCM亚型,并为个性化治疗策略提供信息.

主要方法:

在266名HCM患者和169名健康对照中利用了多维回声心脏学参数 (传统,TDI,STE).
采用主要组件分析和未监督的集群分析来定义基于LV函数的HCM亚型.
在已识别的亚型之间比较临床变量和评估的预后,特别是心房风险.

主要成果:

确定了两个HCM亚型:亚型1 (n=123) 和亚型2 (n=143).
与对照组相比,这两种亚型都表现出 LV 扩张和收缩功能受损,亚型 1 的下降更大.
第1亚型HCM表现出明显的功能特征 (例如,增加应变,减少解率) 和显著更高的心房的风险 (HR:4.34).

结论:

将HCM患者分为两种功能亚型,具有差异性的透静和收缩性表现.
1亚型HCM与心脏功能差以及对心房的易感性增加有关.
这种功能分类为缩性心肌病的有针对性管理提供了潜在的工具.