在患有外周动脉疾病的老年患者中,肌肉损失和血管狭窄的严重程度之间的相关性:使用计算机断层扫描的回顾性分析
Yanyang Zhang1,2, Wenxin Zhao2,3, Zuoguan Chen3
1Department of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Aging clinical and experimental research
|March 12, 2025
概括
周围动脉疾病 (PAD) 的严重程度显著影响下肢肌肉质量和组成. 关键动脉如SFA,PoA和PTA的狭窄导致肌肉减少和脂肪增加,影响患者的预后.
科学领域:
- 血管外科 血管外科
- 放射学 放射学是一门学科.
- 肌肉骨成像系统的成像
背景情况:
- 周围动脉疾病 (PAD) 是一种广泛的疾病,与不良结果有关.
- 骨肌肉损失 (sarcopenia) 在PAD患者中很普遍,并使预后恶化.
研究的目的:
- 评估骨肌面积,密度和脂肪透在PAD患者使用CT.
- 分析这些肌肉参数与血管狭窄程度之间的关系.
主要方法:
- 分析了233名接受下肢CT血管造影 (CTA) 的PAD患者.
- 骨肌的参数 (面积,密度,脂肪透) 被测量在多个腿部水平.
- 下肢动脉狭窄症的严重程度被分级,并计算出CTA得分.
主要成果:
- 较高的血管狭窄得分与男性大腿和小腿肌肉区域的减少有关.
- 患有较高狭窄度得分的患者表现出更大的肌肉间脂肪透.
- 血管狭窄症解释了5%的肌肉质量变异,其中SFA,PoA和PTA狭窄症显示出最强的相关性.
结论:
- 血管狭窄,特别是在SFA,PoA和PTA,在PAD患者中显著影响下肢肌肉质量和组成.
- 严重的狭窄导致肌肉缩和脂肪透增加,可能是由炎症和氧化应激驱动的.
- CT评估为了解PAD肌肉损失提供了一种新的方法,并强调了肌肉健康在管理中的重要性.
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