阴道分娩后的妊娠间隔和单子早产之间的非线性关联:一项回顾性队列研究
Tingting Zhuang1, Yu Zhang2, Xueli Ren3
1Postgraduate Training Base of Jinzhou Medical University (General Hospital of Northern Theater Command), No.83, Wenhua Road, Shenhe District, Shenyang, 110016, China.
BMC pregnancy and childbirth
|March 12, 2025
概括
阴道分娩后11个月或更短的短期间隔 (IPI) 和24个月或更长的长时间间隔 (IPI) 与早产 (PTB) 的风险更高有关. 降低PTB风险的最佳IPI约为23个月.
科学领域:
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产科 产科 产科 产科 产科
背景情况:
- 阴道分娩后的妊娠间隔 (IPI) 和随后的单独早产 (PTB) 之间的关系仍未得到充分研究.
- 了解这种关联对于优化母亲和婴儿的结果至关重要.
研究的目的:
- 调查阴道分娩后的妊娠间隔 (IPI) 与单子妊娠中早产风险 (PTB) 之间的关联.
- 确定最佳的妊娠间隔,以减少PTB风险.
主要方法:
- 利用了2022年国家生命统计系统 (NVSS) 的出生数据.
- 采用多项逻辑回归和限制立方线 (RCS) 模型来分析IPI和PTB之间的关联.
- 进行了值效应分析,使用两部分线性回归来确定非线性关系.
主要成果:
- 对1,517,106名受试者的分析显示,阴道分娩后的IPI与PTB风险之间存在J形关联.
- 与18-23个月参考组相比,≤11个月和≥24个月的妊娠间隔与PTB的风险增加有显著的关联.
- 在约23个月的妊娠间隔中观察到PTB的最低风险.
结论:
- 在阴道分娩后的妊娠间隔 (IPI) 和早产 (PTB) 风险之间存在一个J形的非线性关系.
- 短 (≤11个月) 和长 (≥24个月) 的妊娠间隔与增加PTB风险有关.
- 大约23个月的妊娠间隔似乎是最小化阴道分娩后PTB风险的最佳选择.
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