来自巴西本土植物的生物活性物质具有抗微生物和抗癌活性
Daniele Cristina Vitorelli-Venancio1,2, Rosemary Matias3, Amanda Rodrigues Ganassin3
1Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
BMC complementary medicine and therapies
|March 12, 2025
概括
这项研究强调了巴西塞拉多植物Tapiria obtusa和Smilax fluminensis作为新药的天然来源的潜力. 提取物显示出显著的抗氧化,抗增殖和抗微生物活性对抗耐药性病原体和癌细胞.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
背景情况:
- 迫切需要针对多药耐药微生物和癌症的新疗法.
- 与当前治疗相关的有效性有限,死亡率高.
- 在巴西塞拉多植物中探索生物活性化合物.
研究的目的:
- 评估巴西塞拉多七种植物的植物化学特征.
- 评估植物提取物的抗氧化,抗增殖和抗微生物特性.
- 确定瘤和传染病的潜在治疗剂.
主要方法:
- 通过化制备的植物提取物;进行了植物化学分析.
- 使用DPPH试验测量抗氧化剂活性.
- 对人类癌症和非瘤细胞系进行评估的抗增殖和细胞毒性作用.
- 通过磁盘扩散和微稀释 (MIC) 确定抗菌活性.
主要成果:
- 所有的提取物都含有化合物,黄类,类固醇,素和素.
- 塔皮利亚 obtusa 提取物表现出强大的抗氧化剂 (82.36%) 和针对癌细胞的选择性抗增殖活性 (GI50 10.16 μg/mL).
- 斯米拉克斯·弗鲁明尼斯斯 (Smilax fluminensis) 显示出对Candida glabrata (MIC 500μg/mL) 的杀菌活性,而T. obtusa则显示出对MRSA (MIC 1,000μg/mL) 的抗菌活性.
结论:
- 的乙醇提取物具有显著的抗氧化,抗增殖和抗菌特性.
- 乙醇提取物S. fluminensis叶表现出杀菌作用.
- 这些发现表明,有可能开发新的,更安全的癌症和传染病治疗方法.
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