在一般人口中,FEV1/FVC水平与所有原因死亡率之间的关联
Leheng Tang1, Fan Wu2,3, Shiyu Zhang1
1The First Clinical College, Guangzhou Medical University, Guangzhou, China.
BMC pulmonary medicine
|March 12, 2025
概括
在1秒内强制呼气体积 (FEV1) 与强制生命能力 (FVC) 的比率显示了与一般人群死亡率的U形联系. 较低和较高的FEV1/FVC比率与增加全因死亡风险有关.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- FEV1/FVC比率对于诊断COPD至关重要.
- 它与一般人群全因死亡率的关联,特别是非线性关系,尚不清楚.
研究的目的:
- 调查FEV1/FVC比率水平与一般人群中所有原因死亡率之间的关联.
- 探索潜在的非线性关系.
主要方法:
- 国家健康和营养检查调查数据的分析 (1988-1994,2007-2012).
- 包括年龄≥20岁的参与者进行质量控制的肺功能测试和死亡率随访.
- 考克斯的比例危险模型和受限制的立方线来评估关联和非线性趋势.
主要成果:
- 总共分析了25501名参与者,在308个月的中位数随访期间,死亡人数为6431人.
- 调整后的分析显示,FEV1/FVC<0.90的死亡风险较低,但FEV1/FVC<0.50的风险较高,而FEV1/FVC ≥0.90.
- 限制立方线表明FEV1/FVC比率与全因死亡率之间存在U形关联.
结论:
- 这项研究是首次报告FEV1/FVC比率与一般人群全因死亡率之间的U形关联.
- 非常低的FEV/FVC比率和可能更高的FEV/FVC比率都可能与增加的死亡风险有关.
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