在各种固体瘤癌类型中,在免疫检查点抑制后,BMI升高的患者的生存率有所改善
Eric V Mastrolonardo1, Pablo Llerena1, Emma De Ravin1
1Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Cancer
|March 12, 2025
概括
肥胖与接受免疫检查点抑制剂 (ICI) 治疗的癌症患者的更好的生存率有关. 这项大型研究发现,与正常体重患者相比,肥胖患者在许多固体瘤中改善了整体存活率 (OS).
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 流行病学 流行病学
背景情况:
- 肥胖是已知的癌症风险因素,但也与某些癌症治疗的更好的结果有关 (肥胖悖论).
- 关于肥胖对各种癌症免疫检查点抑制剂 (ICI) 治疗后生存的影响的研究有限.
研究的目的:
- 研究ICI治疗固体瘤患者的肥胖和整体存活率 (OS) 之间的关联.
- 为了比较接受ICI治疗的肥胖和正常体重癌症患者之间的5年OS率.
主要方法:
- 利用TrinetX数据库识别接受ICI (2012-2024) 的各种固体瘤患者.
- 雇员倾向性得分匹配以平衡人口统计,并发症和癌症阶段的队列.
- 在肥胖 (BMI>30) 和正常的BMI (20-24.9) 组之间进行了5年的OS比较.
主要成果:
- 分析包括18434名患者 (9217名肥胖者,9217名正常BMI) 在匹配后.
- 肥胖与所有固体瘤的5年生存率的改善显著相关 (HR,0.69).
- 在肥胖患者中,在多种癌症类型中观察到改善的OS,包括呼吸道,皮肤,头/部,胃肠道,乳腺和泌尿生殖系统.
结论:
- 在患有各种固体瘤的患者中,肥胖与免疫检查点抑制剂治疗后改善的5年整体生存率有关.
- 这项大规模的电子健康记录研究强调了ICI治疗中的肥胖悖论.
- 需要进一步的研究来阐明驱动这种生存益处的潜在机制.
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