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评估MR细胞计成像在区分良性和恶性乳腺瘤的诊断性能

Fan Liu¹, Lei Wu², Xinyi Luo³

¹Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.

Journal of magnetic resonance imaging : JMRI

|March 12, 2025

概括

扩散MRI技术MR细胞测量有效地区分良性和恶性乳腺瘤. 在生物物理建模中纳入跨细胞体水交换显著提高了乳腺癌检测的诊断准确性.

科学领域:

生物医学成像技术生物医学成像技术
放射学放射学是一门学科.
在瘤学瘤学.

背景情况:

核磁共振细胞计使用扩散核磁共振 (MRI) 来分析细胞水平上的瘤微观结构.
多个b和扩散时间数据的多部门生物物理建模产生了微观结构参数.
这些参数显示了改善良性和恶性乳腺瘤分化的潜力.

研究的目的:

实施MR细胞测量与跨细胞体水交换 (JOINT和EXCHANGE) 进行乳腺瘤分化.
比较IMPULSED,JOINT和EXCHANGE MR细胞计方法的分类疗效.
在乳腺癌评估中评估先进MR细胞测量技术的诊断性能.

主要方法:

一项前性研究涉及115名病理确诊乳腺瘤患者.
使用3TMRI与脉冲和振荡梯度旋回回声扩散加权成像.
计算了依赖时间的ADC和微观结构参数,包括细胞直径,体积分数和水交换率.

主要成果:

与ADC (0.822) 和IMPULSED (0.840) 相比,结合跨细胞膜水交换 (JOINT,EXCHANGE) 的MR细胞计方法显示出更高的性能 (AUC:0.902-0.905).
结合指标进一步提高了分类准确性,JOINT 实现了 0.956.95 的 AUC.
这些改善在整个队列和年龄调整后的子组中都是一致的.

结论:

在区分良性与恶性乳腺瘤方面,MR细胞计显著优于ADC.
将跨细胞体水交换集成到生物物理模型中,提高了MR细胞计的诊断能力.
先进的MR细胞测量技术为乳腺癌诊断提供了一个有希望的非侵入性方法.

关键词:

在MR细胞测量中使用MR细胞测量.良性 - 恶性恶性乳腺瘤是什么乳腺瘤是什么扩散磁力共振成像 (MRI) 扩散跨cytolemmal 交换水的交换.

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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...