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系统性红血性狼患者的死亡率

Jia Yi Tan¹, Arya Mariam Roy², Michael Guma³

¹Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, NJ, USA.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

|March 12, 2025

概括

在过去二十年中,系统性狼发疹 (SLE) 患者的癌症死亡率有所增加. 在妇女和非裔美国人中观察到较高的死亡率,表明需要有针对性的干预措施.

科学领域:

流行病学流行病学
在瘤学瘤学.
类风湿病学类风湿病学

背景情况:

系统性红斑狼 (SLE) 与各种癌症的风险增加有关,包括血液性恶性瘤.
美国SLE患者的癌症死亡率趋势需要进一步调查.

研究的目的:

分析过去二十年 (1999-2020年) 在美国被诊断患有SLE的患者癌症死亡率的趋势.

主要方法:

一项利用CDC WONDER数据库进行的横截面研究,以检查从1999年到2020年SLE患者的癌症死亡率.
计算了年龄调整的死亡率 (AAMR),并使用结点趋势分析来确定年平均百分比变化 (AAPC).

主要成果:

在1999年至2020年期间,在SLE患者中共记录了2481例癌症死亡.
在SLE患者中,癌症的总体AAMR从0.71上升到1.19/1,000,000,AAPC为+1.19%.
与男性 (0.29/百万) 相比,女性 (1.39/百万) 和非裔美国人 (1.23/百万) 的AAMR较高,而非裔美国人 (1.23/百万) 与其他种族/族群相比.

结论:

在过去二十年中,SLE患者的癌症死亡率呈现出越来越高的趋势.
癌症死亡率存在显著差异,尤其是女性和非裔美国人的死亡率更高.
这些发现强调了针对SLE人口,特别是高风险人口群体的向癌症预防和干预策略的必要性.

关键词:

类风湿病学类风湿病学自身免疫性疾病是一种自身免疫性疾病.生物的生物的生物的生物.癌症癌症癌症癌症癌症流行病学流行病学瘤学在瘤学方面.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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