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非侵入性眼部纳米颗粒药物输送的趋势:一个文献计量分析 (2004-2023)

Dan Li1, Qing Ye1, Chao Li1

  • 1Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Jiangsu Province, China.

Biomolecules & biomedicine
|March 12, 2025
PubMed
概括

本文献分析揭示了对眼睛表面的非侵入性纳米粒子药物输送的日益增长的研究趋势. 关键主题包括受控释放和增强的角膜透,突出显著的全球贡献.

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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