在CYP2C19多态和质子抑制剂药物不良反应之间的关联:一个叙事审查
Asmaa Ibrahim1, Kazeem Yusuff1, Ahmed Awaisu1
1Department of Clinical Pharmacy and Practice, College of Pharmacy, Qatar University, Doha, Qatar.
Frontiers in pharmacology
|March 12, 2025
概括
质子抑制剂 (PPI) 是常见的降酸药物. 本综述检查了与CYP2C19基因变异相关的长期不良药物反应 (ADR),解决了相互矛盾的研究结果.
科学领域:
- 药物基因组学 药物基因组学
- 药品安全 药品安全
- 胃肠病学 胃肠病学
背景情况:
- 质子抑制剂 (PPI) 经常用于与酸有关的胃肠道疾病.
- 人们对与PPI使用相关的长期不良药反应 (ADR) 存在担忧.
- 由于不一致的发现,CYP2C19遗传多态化对PPI相关的副作用的影响需要进一步调查.
研究的目的:
- 审查和综合目前关于PPI长期ADRs的证据.
- 探索PPI诱导的ADR与CYP2C19遗传变异之间的关联.
主要方法:
- 对观察性研究的系统文献综述.
- 对研究PPI,ADR和CYP2C19多态性的研究进行分析.
主要成果:
- 调查PPI,ADR和CYP2C19变体之间的联系的观察性研究产生了相互矛盾或微弱的结果.
- 需要进一步的研究来澄清确切的关系和临床影响.
结论:
- PPI,长期ADR和CYP2C19多态之间的关联需要更强大的研究.
- 了解这些药物遗传相互作用对于个性化的PPI治疗和患者安全至关重要.
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