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脂肪分布对不同性别左心室结构和功能的影响:孟德尔的随机化研究

Hang Li¹, Guangjiao Yin^1,2, Yanfang Zhang¹

¹Department of Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Frontiers in endocrinology

|March 12, 2025

概括

腰部至部比率 (WHR) 因果影响左心室 (LV) 结构和功能,特别是在女性中. 脂肪分布模式在性别之间独特地影响心脏健康,突出性别特异性心血管风险.

科学领域:

心血管遗传学心血管遗传学
肥胖医学肥胖医学
心脏生理学心脏生理学

背景情况:

性别,身体脂肪分布和心脏结构/功能之间的相互作用是复杂的,并未完全理解.
以前的研究表明存在联系,但因果关系需要进一步阐明.
了解这些联系对于性别特异性心血管风险评估至关重要.

研究的目的:

研究影响脂肪分布模式的遗传因素与左心室 (LV) 结构和功能之间的因果关系.
为了确定这些关系是否在性别之间有所不同.
使用门德尔的随机化来探索因果关系.

主要方法:

来自欧洲GWAS的腰围,部周长,腰与部比率 (WHR) 和体重指数 (BMI) 的精选遗传变异.
利用英国生物库心血管磁共振数据 (> 35,000 个欧洲样本) 来确定 LV 参数.
采用双样本的门德尔随机化 (MR) 分析来评估因果关系.

主要成果:

经BMI调整后,WHR显示与LV缩有积极的因果关系,与LV体积和扩张功能有负面联系.
这些关联在女性 (FWHR) 中显著,但在男性 (MWHR) 中没有显著.
在WHR和LV射出分数 (LVEF) 之间没有观察到因果关系.

结论:

脂肪分布模式对LV结构和功能产生明显的影响,性别特异性差异很大.
提供了脂肪分布在调节不同性别的心脏结构和功能的因果作用的证据.
强调在了解与肥胖有关的心血管风险时考虑性别特异性的方法的重要性.

关键词:

门德尔的随机化脂肪的分布模式脂肪的分布模式左心室的结构和功能.性别差异的性别差异.腰部与部的比率是什么

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