在SARS-CoV-2患者的Ruminococcus gnavus Bacteremia中,患者患有性硬化症
Raquel Flores1, Paula A Calvo2, Constanca Antunes3
1Internal Medicine, Hospital de Egas Moniz, Lisbon, PRT.
Cureus
|March 12, 2025
概括
肠道细菌Ruminococcus gnavus可以在免疫受损的个体中引起细菌病. 这一案例凸显了用皮质类固醇治疗的并发症和SARS-CoV-2感染患者的风险.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 鲁米诺科克 (Ruminococcus gnavus) 是人类肠道微生物群的正常居民.
- 与慢性疾病和免疫抑制相关的肠道失生症可以导致细菌转移.
- 鲁米诺科克斯 (Ruminococcus gnavus) 菌血症是一种罕见但严重的并发症.
研究的目的:
- 报告Ruminococcus gnavus bacteremia的病例,该病例发生在患有多种并发病的老年患者身上.
- 审查有关Ruminococcus gnavus细菌病例的文献.
- 探索潜在的促成因素,包括SARS-CoV-2感染和皮质类固醇治疗.
主要方法:
- 一个老年男性患者的病例介绍,他患有Ruminococcus gnavus bacteremia.
- 使用PubMed使用Ruminococcus gnavus细菌病例的文献综述 (2023年8月搜索).
- 分析患者的并发症和治疗方法,包括SARS-CoV-2感染和皮质类固醇使用.
主要成果:
- 这位患者出现了Ruminococcus gnavus细菌病,长时间住院,以及多种传染性并发症.
- 在文献搜索中,发现了17例先前报告的Ruminococcus gnavus bacteremia的病例.
- 常见报告的诱导因素包括胃肠道问题 (出血,分管疾病,大肠炎,胆囊炎,) 和骨科假肢感染.
- 一个以前的案例涉及一个患有血液瘤疾病的患者,接受了皮质类固醇治疗.
结论:
- 鲁米诺可克菌根菌病可能发生在具有重大并发症的患者中.
- 免疫抑制,可能会被SARS-CoV-2感染的皮质类固醇治疗加剧,可能会导致Ruminococcus gnavus转位和细菌病.
- 脊椎病是Ruminococcus gnavus bacteremia的重要危险因素之一.
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