在COVID-19患有严重肝功能障碍的患者中确定VV116的剂量:病例报告
Jing Yang1, Wenwen Jiang2, Jianqing Deng2
1Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in medicine
|March 12, 2025
概括
对SARS-CoV-2的口服抗病毒药物VV116在患有严重肝功能障碍的患者中成功使用. 这个案例展示了药物的药物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 病毒学 病毒学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 严重的肝功能障碍给抗病毒药物选择带来了挑战.
- VV116是一种用于SARS-CoV-2的口服抗病毒药物,具有已知的安全性.
- 关于VV116在严重肝功能障碍患者中使用的数据有限.
研究的目的:
- 评估VV116在患有SARS-CoV-2和严重肝功能障碍的患者中的安全性和有效性.
- 在这个特定的患者群体中确定适合VV116的降低剂量方案.
主要方法:
- 一个病例报告,一名患有无塑性贫血和肝功能障碍 (急性肝功能衰竭恢复阶段) 的患者感染了SARS-CoV-2.
- 减少VV116的剂量:在第1天每12小时服用300毫克,然后在第2-5天每12小时服用200毫克.
- 病毒载荷的监测和评估与药物相关的不良影响.
主要成果:
- 患者的SARS-CoV-2病毒载量迅速降低到无法检测的水平.
- 在治疗期间没有观察到与药物相关的不良反应.
- 减少的VV116剂量方案被很好地容忍.
结论:
- VV116可以安全有效地给患有严重肝功能障碍的患者使用,例如从急性肝衰竭中恢复过来的患者.
- 在肝功能受损的患者中,精心调整的VV116降低剂量可能是SARS-CoV-2的可行的抗病毒策略.
- 这一案例凸显了VV116在复杂患者个人资料中管理COVID-19的潜力.
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