成年IgA血管炎与癌症之间的关联:一项前性观察性研究
Alojzija Hočevar1,2, Vesna Jurčič3, Žiga Rotar1,2
1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Frontiers in medicine
|March 12, 2025
概括
癌症与成年人IgA血管炎 (IgAV) 有关,7.5%的患者患有癌症. 前列腺癌,癌和膀癌在IgAV相关癌症病例中最常见.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- IgA血管炎 (IgAV) 是一种自身免疫性疾病,其与成人癌症的关联尚未确立.
- 关于成年人群中可能与IgAV相关的癌症的频率和特定类型的数据有限.
研究的目的:
- 为了调查成年患者诊断出IgA血管炎的癌症发生频率.
- 为了确定与成年人IgAV相关的癌症的类型和位置.
- 探索IgAV诊断和癌症发展之间的时间关系.
主要方法:
- 在2010年至2021年间诊断的295名成年IgAV患者的回顾性分析.
- 根据相对于IgAV诊断的时间来对癌症诊断进行分类 (之前,同时或随访期间).
- 关于IgAV相关癌症 (IgAV-CA) 的定义,用于呈现活跃癌症的病例或在IgAV诊断周围的三年窗口内.
主要成果:
- 近16%的IgAV患者 (47/295) 患有癌症,其中7.5%被归类为IgAV-CA.
- 大多数癌症 (76.8%) 在IgAV.之前被诊断出来.
- 前列腺癌,癌和膀癌在IgAV-CA组中最常见,占病例的50%.
结论:
- 癌症与大约7%的成年IgAV病例有关.
- 年龄和吸烟与并发性癌症有关,而关节炎是IgAV随访期间癌症的危险因素.
- 在怀疑患有癌症的老年患者中,建议对泌尿器官系统进行彻底检查.
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