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Updated: May 12, 2026

Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells
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Published on: October 4, 2017

对SOD1的结构洞察:从体和分子动力学到ALS相关的E49K和R115G突变体的实验分析

Seyed Mahdi Hosseini Faradonbeh1, Bagher Seyedalipour1, Nasrin Keivan Behjou1

  • 1Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran.

Frontiers in molecular biosciences
|March 12, 2025
PubMed
概括

与肌缩侧硬化症 (ALS) 相关的铜/超氧化物脱酶1 (SOD1) 中的突变破坏了蛋白质结构的稳定. 这些变化促进了错误折叠和有毒物种的形成,有助于ALS的发病.

关键词:
这就是ALS.在E49K中使用.在R115G中,使用R115G.人类超氧化物脱酶-1蛋白质聚合蛋白质的聚合物蛋白质的稳定性 蛋白质的稳定性蛋白质结构 蛋白质结构

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