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Updated: May 23, 2025

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瘤性病毒对SIRPα-Fc的表达通过瘤微环境重编程增强了抗瘤功效

Qingzhe Yang1, Yongheng Shu1, Yanwei Chen1

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in immunology
|March 12, 2025
PubMed
概括

工程化瘤性腺病毒 (oAdVs) 表达SIRPα-mIgG1Fc (oAd-SA) 增强了巨细胞细胞和T细胞功能. 这种新型免疫疗法在临床前模型中显示出优异的瘤回归,为全身癌症治疗提供了一个有前途的战略.

关键词:
这就是SIRPα.型瘤性腺病毒瘤免疫疗法 免疫疗法瘤微环境是一个微环境.与瘤相关的巨细胞.

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