手术前的SII可以预测手术后的复发和严重并发症在患有肝病的患者
Tianyang Mao1,2,3, Xin Zhao1,2, Kangyi Jiang1,2
1Department of Hepatobiliary Surgery, The People's Hospital of Leshan, Leshan, People's Republic of China.
Journal of inflammation research
|March 12, 2025
概括
高的全身免疫指数 (SII) 表明肝瘤手术后复发和严重并发症的风险增加. 在这些患者中,较低的SII水平与更好的无复发生存率 (RFS) 相相关.
科学领域:
- 肝胆道手术是肝胆道的手术.
- 炎症标志物是一种炎症标志物.
- 外科手术的结果
背景情况:
- 肝病涉及炎症反应和免疫蛋白质.
- 预测无复发生存率 (RFS) 和术后并发症对于患者管理至关重要.
研究的目的:
- 评估肝病患者的全身免疫指数 (SII) 和RFS之间的关系.
- 评估SII和严重的术后并发症之间的关联.
主要方法:
- 对177名肝病患者的回顾性分析.
- 使用ROC曲线分析来确定炎症指数 (SII,SIRI,NLR,MLR,PLR,PNI) 的最佳切断值.
- 采用千平方测试,逻辑回归,卡普兰-梅尔和考克斯回归分析来评估与临床结果的关系.
主要成果:
- 系统免疫指数 (SII),手术方法和单细胞/淋巴细胞比率 (MLR) 是严重的术后并发症和RFS的独立风险因素.
- 高的手术前SII,SIRI和NLR水平与复发率的增加有关.
- 低SII,SIRI和NLR水平的患者表现出显著更高的RFS.
结论:
- 手术前的全身免疫指数 (SII),全身炎症反应指数 (SIRI) 和中性粒细胞/淋巴细胞比率 (NLR) 与肝病的术后复发有关.
- SII是RFS和肝瘤手术后严重并发症的独立风险因素.
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