在管理后COVID-19嗅觉功能障碍的不同方式
Ahmed Shehata El Sayed Saleh1,2, Ayman Abdelaal Mohamady1, Mostafa Gomaa Sobhey1
1Otorhinolaryngology Department, Faculty of Medicine, Benha University, Benha, Qalyubia Egypt.
概括
像鼻类固醇,维生素A和神素这样的治疗方法可能会加快COVID-19后的气味恢复. 然而,这些疗法在四周后,与单独的嗅觉训练相比,没有显著改善嗅觉得分.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- SARS-CoV-2 感染经常导致嗅觉功能障碍,影响患者的生活质量.
- 支持有效治疗COVID-19后嗅觉功能障碍的证据仍然有限.
- 嗅觉训练是一种常见的干预措施,但它的有效性可以提高.
研究的目的:
- 为了评估鼻子类固醇,鼻子维生素A和鼻腔神在治疗COVID-19后嗅觉功能障碍时的疗效.
- 为了比较接受这些治疗与嗅觉训练相结合的患者的恢复时间和嗅觉得分.
- 确定可能影响嗅觉功能障碍持续时间和严重程度的因素.
主要方法:
- 这是一项多中心追溯病例对照研究,涉及120名患有COVID-19后嗅觉功能障碍 (低或无) 的患者.
- 患者接受了单独的嗅觉训练 (对照组) 或与鼻类固醇,鼻维生素A或鼻内神素相结合的嗅觉训练.
- 收集的数据包括人口统计,病史,COVID-19的持续时间和气味恢复指标.
主要成果:
- 与单独的嗅觉训练相比,鼻类固醇,鼻维生素A和鼻神素显著减少了完成嗅觉恢复的时间 (25.7 ± 9.20天,24.8 ± 6.67天,23.5 ± 7.13天与28.97 ± 4.29天相比,P=0.02).
- 在年龄,性别,COVID-19严重程度或肥胖以及嗅觉功能障碍的持续时间之间没有发现显著的相关性.
- 糖尿病,高血压,吸烟和喘与在四周内完全恢复气味的时间更长有显著联系 (P<0.001).
结论:
- 将局部使用的mometasone furoate,维生素A或鼻腔内Theophylline与嗅觉训练相结合,可能会缩短COVID-19后嗅觉功能障碍的持续时间.
- 尽管恢复时间更快,但与单独的嗅觉训练相比,四周后没有观察到嗅觉得分的显著改善.
- 糖尿病,高血压,吸烟和喘等并发症会在四周内对完全的气味恢复产生负面影响.
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