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差异化甲状腺癌与远程转移的疾病特异性死亡率

Ali Howaidi^1,2, Anwar Alswailem¹, Abdulrhman Hakami³

¹Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.

Journal of the Endocrine Society

|March 12, 2025

概括

差异化甲状腺癌 (DTC) 的远程转移是致命的. 随着年龄的增长和骨转移显著预测了DTC患者远程转移的死亡率.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
癌症研究癌症研究

背景情况:

远程转移 (DM) 是差异化甲状腺癌 (DTC) 的首要死亡原因.
确定DM的DTC患者死亡率的预测因素对于改善结果至关重要.

研究的目的:

在差异化甲状腺癌患者中调查与远程转移相关的死亡预测因素.

主要方法:

来自机构瘤登记册的86名DMDTC患者的回顾性分析.
收集的数据包括患者人口统计数据,治疗方式 (甲状腺切除术,部切割,I-131切除),转移部位和随访时间.
使用统计分析,包括多变量分析,以确定死亡率预测因素.

主要成果:

肺转移最常见 (91.9%),其次是骨转移 (58.1%) 和大脑转移 (9.3%).
总体疾病特异性死亡率为54.7%,平均随访时间为84个月.
年龄的增加 (HR 1.030) 和骨转移 (HR 2.58) 是死亡率的显著预测因素.

结论:

在DTC的远程转移与高死亡率有关 (约. 在55%的比例下,55%).
患者年龄的增加和骨转移的存在是远程转移的DTC患者死亡的重要风险因素.

关键词:

骨转移发生在骨髓中.有差异化的甲状腺癌.遥远的转移遥远的转移肺转移是肺的转移.死亡率死亡率甲状腺癌是一种癌症.

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