从表皮和介质细胞表型的球状体作为生物打印中的构建块 (评论)
D P Revokatova1, P I Koteneva2, N V Kosheleva3
1Junior Researcher, Laboratory of Clinical Smart- and Nanotechnologies, Institute of Regenerative Medicine; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia.
Sovremennye tekhnologii v meditsine
|March 12, 2025
概括
了解表皮和介质球体的机械特性对于在再生医学中推进3D生物打印至关重要. 本综述比较了它们的特性和生物打印应用.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 细胞生物学 细胞生物学
背景情况:
- 组织包括上皮细胞和介质细胞,对屏障功能,新陈代谢,支持和重塑至关重要.
- 细胞相互作用是身体完整性的关键;组织工程旨在通过人工结构来复制这一点.
- 三维 (3D) 生物打印利用细胞球体作为工程组织的构建块.
研究的目的:
- 审查和比较表皮和介质细胞球体的机械特性.
- 检查可再生医学应用的共同培养方法.
- 分析球形体在生物打印中的利用,以开发高质量的组织结构.
主要方法:
- 关于球体机械特性研究的文献综述.
- 对表皮细胞和介质细胞的共同培养技术的分析.
- 评估使用球体的生物打印策略.
主要成果:
- 在表皮相对于介质球体的机械性质上存在显著的差异.
- 球体的机械特性影响细胞迁移,融合和构造形态.
- 共同培养和特定的生物打印方法对于成功的组织工程至关重要.
结论:
- 精确了解球形力学对于优化3D生物打印至关重要.
- 根据细胞类型特性定制生物打印方法可以提高组织结构质量.
- 这种知识对于推进再生医学和创造功能性人工组织至关重要.
相关概念视频
Tissues
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
Types of Membrane Protrusions
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
The microvilli, an example of stable protrusions, are finger-like projections with a...
Zygotic Development And Stem Cell Formation
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Cell Diversity
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
Multicellular organisms...
Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Cells of the Epidermis
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...


