网症:自身免疫,COVID-19和长期COVID的关键参与者
Diana M Monsalve1, Yeny Acosta-Ampudia1, Nicolás Guerrero Acosta1
1Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Journal of translational autoimmunity
|March 12, 2025
概括
中性细胞细胞外陷 (NET) 释放,或NETosis,是主体防御和自身免疫的关键. 在COVID-19和长期COVID中失调的NETosis可能会导致严重的并发症和自身免疫性疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 中性粒细胞细胞外陷释放的NETosis对于宿主防御和自身免疫性疾病的发病至关重要.
- SARS-CoV-2 感染涉及中性粒细胞激活;失调的 NETosis 与 COVID-19 严重程度,凝血病和内皮损伤相关.
- 长期COVID的特点是持续的炎症,过度的NETosis与正在进行的病理生理变化有关.
研究的目的:
- 审查NETosis在自身免疫性疾病中的作用.
- 探索COVID-19,长期COVID和自身免疫之间的联系,包括分子模仿和表位细胞传播.
- 讨论在SARS-CoV-2感染中NETosis标记物和免疫反应.
- 检查针对COVID-19和长期COVID并发症的NETosis的治疗策略.
主要方法:
- 文献综述和综合现有关于NETosis,自身免疫和COVID-19的研究.
- 分析将SARS-CoV-2与NETosis和自身免疫现象联系在一起的机制.
- 讨论当前和潜在的治疗干预措施.
主要成果:
- NETosis在宿主防御和自身免疫病原发生过程中起着双重作用.
- 失调的NETosis与严重的COVID-19结果有关,包括凝血病和内皮损伤.
- 过度的NET形成越来越被认为是长期COVID病理生理学和持续性炎症的贡献者.
- NETosis机制与SARS-CoV-2感染后自身免疫的发展和恶化有关.
结论:
- 网症是自身免疫性疾病和SARS-CoV-2感染的关键因素.
- 针对失调的NETosis为管理严重的COVID-19和长期COVID并发症提供了一个有希望的治疗途径.
- 对NETosis调节的进一步研究可以提供减轻病毒感染长期自身免疫后续的策略.
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