在患有创伤后应激障碍的退伍军人中戒烟的行为激活:随机临床试验
Jesse T Kaye1,2, Jennifer M Betts1,2,3, Elana Brubaker3
1Center for Tobacco Research and Intervention, University of Wisconsin Madison School of Medicine and Public Health, 1930 Monroe St #200, Madison, WI 53711.
概括
行为激活 (BA) 在标准治疗中添加后应激障碍的美国退伍军人中没有改善戒烟率. 这种戒烟干预措施并没有使精神病症状恶化.
科学领域:
- 精神病学是一个精神病学.
- 行为科学 行为科学
- 成 药物 药物 药物 药物
背景情况:
- 戒烟对于患有精神疾病,特别是创伤后应激障碍 (PTSD) 的人来说是具有挑战性的.
- 在创伤后应激障碍中常见的无情感与戒烟困难有关.
- 行为激活 (BA) 针对安赫多尼亚,并显示出增强戒烟治疗的潜力.
研究的目的:
- 评估行为激活 (BA) 是否作为标准戒烟治疗的辅助,可以提高患有PTSD的美国退伍军人的戒烟率.
- 为了将BA与注意力控制条件进行比较,当两者都添加到标准护理中时.
主要方法:
- 一个随机临床试验,涉及美国退伍军人被诊断患有PTSD.
- 参与者接受了为期8周的BA或健康吸烟教育咨询 (控制),以及标准的戒烟咨询和组合尼古丁替代疗法.
- 主要结局是在戒烟后26周的生化证实的7天点患病率禁欲.
主要成果:
- 在BA组 (15.9%) 和对照组 (11.5%) 之间,在26周内生化证实的戒烟率没有显著差异.
- 在各个随访点 (4,12,20,26周) 上,自我报告的戒断率也没有显著差异.
- 戒烟干预措施与精神病症状恶化无关.
结论:
- 行为激活疗法,当添加到标准的戒烟治疗和药物治疗时,与注意力控制条件相比,在患有PTSD的美国退伍军人中没有显著增加吸烟戒断率.
- 这些发现表明,在这个人群中,BA可能不会比注意力控制更有效地帮助戒烟.
- 重要的是,戒烟治疗没有导致精神症状恶化,这表明安全性.
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