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接种COVID-19疫苗对持续性COVID-19后疾病风险的影响:队列研究
Pontus Hedberg1, Suzanne Desirée van der Werff2,3, Pontus Nauclér2,3
1Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
The Journal of infectious diseases
|March 12, 2025
概括
接种COVID-19疫苗可以显著降低患COVID-19后持续性疾病 (PCC) 的风险. 多个疫苗剂量在SARS-CoV-2感染的幸存者中提供了对长期COVID症状的更大保护.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 持续的COVID-19后疾病 (PCC) 构成了全球重大健康挑战.
- 了解风险因素,包括疫苗接种情况,对于缓解PCC至关重要.
- 以前的研究表明,接种PCC疫苗可能有好处,但需要更多的数据.
研究的目的:
- 调查COVID-19疫苗接种与患有持续性PCC的风险之间的关联.
- 量化与不同数量的疫苗剂量相关的风险降低.
- 探索这些跨不同SARS-CoV-2变体和人口学子组的关联.
主要方法:
- 在瑞典斯德哥尔摩进行基于人口的队列研究.
- 包括331,042个在SARS-CoV-2感染后的第一年幸存下来的个体.
- 与未接种疫苗的个人相比,针对1,2,3剂疫苗的调整风险比率计算.
主要成果:
- 在接种疫苗时观察到PCC风险的剂量依赖性降低.
- 调整后的风险比为0.81 (95% CI, .59-1.10) 的1剂量,0.42 (95% CI, .35-.52) 的2剂量,和0.37 (95% CI, .27-.52) 的3剂量.
- 降低的风险在Omicron前和Omicron变种以及各种子组中一致.
结论:
- 接种COVID-19疫苗与患上COVID-19后持续性疾病的风险大大降低有关.
- 较高的疫苗剂量为长期的COVID提供了更大的保护.
- 疫苗接种仍然是管理SARS-CoV-2感染的长期健康后果的关键策略.
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