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Updated: May 22, 2025

Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined Workflow
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过程优化减轻了Fc融合蛋白在超过/透过过程中的保留损失

Hao Yu1, Li Fei1

  • 1Downstream Process Development (DSPD), WuXi Biologics, Shanghai, China.

Biotechnology progress
|March 12, 2025
PubMed
概括

超过/透过 (UF/DF) 对于抗体治疗至关重要. 过程优化,考虑到pH和度两极分化,改善了Fc-fusion蛋白质保留超出了膜分子重量切割值,提高了产量和质量.

关键词:
在Fc-fusion蛋白质中.超过/透过的方法度两极分化度两极分化形状的变化 形状的变化料流量是指料的流量.保持损失的保留损失.通过膜的压力压力.

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