终身经典迷幻药的使用和头痛:一个横截面研究.
Zusanna Bjurenfalk1, Alva Cosmo1, Otto Simonsson2
1Department of Neuroscience, Centre for Cluster Headache, Karolinska Institutet, Stockholm, Sweden.
Journal of psychopharmacology (Oxford, England)
|March 12, 2025
概括
经典迷幻药的终身使用与频繁严重头痛减少25%有关. 这一发现表明,迷幻药可能为偏头痛等主要头痛疾病提供一种新的预防性治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 流行病学 流行病学
背景情况:
- 偏头痛和集群头痛是主要的头痛疾病,常规治疗选择有限.
- 经典的迷幻药物,包括 lysergic acid diethylamide (LSD) 和 psilocybin,显示出作为这些疾病的新疗法药物的潜力.
研究的目的:
- 检查一生经典迷幻药物使用与频繁严重头痛的患病率之间的关联.
- 为了研究幻觉药物在管理主要头痛障碍中的潜力,在一个大规模的英国队列中.
主要方法:
- 从1958年英国国家儿童发展研究 (收集1999-2000年) 中的11,419名参与者的数据进行横截面分析.
- 采用多种物流回归模型,控制潜在的混因素.
- 这项研究测试了这种假设,即经典的迷幻药使用与频繁出现严重头痛的几率降低有关.
主要成果:
- 经典迷幻药的终身使用与报告频繁严重头痛的几率下降25%显著相关 (调整后几率比率=0.75,95% CI:0.59-0.95,p=0.016).
结论:
- 这些发现支持越来越多的证据表明,经典的迷幻药作为一种潜在的预防性治疗主要头痛障碍的潜在治疗方法.
- 对偏头痛和集群头痛等疾病的迷幻辅助疗法的进一步研究是有必要的.
相关概念视频
Hallucinogens and Psychedelics
150
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
150
CNS Stimulants: Psychedelic Agents
114
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
114
Altered States of Awareness
145
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
145


