对对科里尼细菌 (Corynebacterium) 物种进行体外活动的评估
Saltanat Ualiyeva1, Justin McCallum1, Alexander Donald Pyden2
1Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
奥马达环素对Corynebacterium物种表现出有前途的活性,在汁微稀和MIC测试条方法之间存在重要的协议,支持其临床实用性. 这种四环素为这些新兴病原体引起的感染提供了潜在的新疗法.
科学领域:
- 微生物学 微生物学
- 抗生素敏感性测试 抗生素敏感性测试
- 传染性疾病 传染性疾病
背景情况:
- 科里内细菌物种越来越多地被确定为重要的人类病原体.
- 需要有效的抗微生物药物来对抗这些格拉姆阳性细菌.
研究的目的:
- 为了评估omadacycline在实验室中的活性与Corynebacterium物种的临床分离物.
- 为了比较两种方法来确定奥马达环素最小抑制度 (MICs):微稀释 (BMD) 和Liofilchem奥马达环素MIC测试条 (MTS).
主要方法:
- 测试了Corynebacterium的40种临床分离物.
- 最低抑制度 (MIC) 用微稀释 (BMD) 作为参考方法来确定.
- 使用Liofilchem的奥马达环素MIC测试条 (MTS) 也确定了MIC.
主要成果:
- 对于对抗Corynebacterium分离物的奥马克林的MIC范围是0.12-2.0μg/mL.
- 根据BMD,MIC50和MIC90分别为0.5微克/毫升和1微克/毫升.
- 骨硬化和MTS之间的基本一致性为87.5% (95%CI:73.0%-95.4%).
结论:
- 奥马达环素在体外表现出强烈的抗科里尼细菌物种的活性.
- 利奥菲尔希姆的奥马达环素MTS提供了与BMD参考方法基本一致的结果,表明其适用于常规敏感性测试的适用性.
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