患有MASLD的人患有严重细菌和非细菌感染的风险
Giovanni Targher1,2, Herbert Tilg3, Luca Valenti4,5
1Department of Medicine, University of Verona, Verona, Italy.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了严重细菌和病毒感染的风险,特别是晚期肝病. 了解这些联系对于管理这个日益严重的全球健康问题至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是全球慢性肝病的主要原因.
- MASLD是一种多系统性疾病,与心血管,脏和癌症并发症有关.
- 新出现的证据将MASLD与需要住院治疗的严重感染风险增加联系在一起.
研究的目的:
- 审查有关MASLD和感染风险的流行病学数据.
- 探索与MASLD相关的感染易感性增加背后的机制.
- 讨论对管理MASLD患者的临床影响.
主要方法:
- 现有文献的叙述性审查.
- 对MASLD和感染发病率的流行病学研究的分析.
- 检查拟议的病理生理机制.
主要成果:
- 观察性研究始终表明,MASLD与严重细菌感染 (SBI) 之间存在积极的关联.
- 感染风险随着MASLD的严重程度而升级,特别是在肝硬化中.
- 增加的易感性扩展到像SARS-CoV-2这样的病毒感染.
结论:
- MASLD显著增加了严重细菌和病毒感染的风险.
- 免疫功能障碍,特别是肝硬化,有助于感染易感性.
- 对于高感染风险的MASLD患者,需要临床意识和管理策略.
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