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Updated: May 22, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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致白血病的克拉斯突变重新编程多强的祖先,以促进其通过造血系统的传播

Geunhyo Jang1, Rosa Park2, Eduardo Esteva1,3

  • 1Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.

The Journal of experimental medicine
|March 12, 2025
PubMed
概括

像KrasG12D这样的转变突变通过重编程多能原始体 (MPP) 来加速白血病的发展. 这通过干细胞/祖细胞电路产生了白血病前状态,影响了造血干细胞 (HSC) 的贡献.

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