相关实验视频

Updated: May 22, 2025

Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities

Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities

Published on: January 6, 2023

UCNPs@PVP-Hemin-GOx@CaCO₃ 纳米平台用于铁灭的自我放大,与过载相结合

Yuping Xu¹, Mingming Ren¹, Runzhi Deng²

¹National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.

Advanced healthcare materials

|March 12, 2025

概括

一种新的纳米复合材料,UPHGC NPs,通过结合光动力学疗法,化学动力学疗法和饥饿疗法,提供多式协同的癌症治疗. 这种方法有效地准瘤微环境,并诱导自我放大铁灭,以增强瘤细胞死亡.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

瘤微环境的复杂性阻碍了当前的癌症治疗方法.
需要先进的治疗策略来克服治疗耐药性.

研究的目的:

开发一种对TME敏感的纳米复合材料,用于多模式协同疗法.
研究UPHGCNP在诱导铁亡和瘤细胞死亡方面的疗效.

主要方法:

在UCNPs@PVP-Hemin-GOx@CaCO3 (UPHGC) 纳米复合材料的制造.
在体外和体内对UPHGCNP进行光动力学疗法 (PDT),化学动力学疗法 (CDT) 和饥饿疗法 (ST) 的评估.
评估ferroptosis诱导,反应性氧物种 (ROS) 生成和过载.

主要成果:

UPHGC NPs显示了PDT,CDT和ST的协同作用,导致放大铁亡.
血红素促进了ROS的产生和谷氨的耗尽,增强了脂质过氧化.
葡萄糖氧化酶 (GOx) 放大了ROS生成和葡萄糖酸释放,促进了过载和线粒体功能障碍.
碳酸涂层可以防止药物过早释放,确保有针对性的输送.

结论:

UPHGC NPs为癌症提供了一个有前途的多模式协同治疗策略.
响应TME的设计和自我放大的铁灭诱导在癌症治疗方面取得了重大进展.
这种方法有可能克服治疗耐药性并改善患者的治疗结果.

关键词:

在CDT/PDT/ST中使用.过量的过载铁化是铁化的一种.在这里,Hemin.协同作用的瘤治疗方法

更多相关视频

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

Published on: January 30, 2018

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

相关概念视频

C4 Pathway and CAM

C4 Pathway and CAM

Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...

Habitat Fragmentation

Habitat Fragmentation

Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.

Ecological Niches

Ecological Niches

All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.