在接受年度检查的成年人中,酒精消费的变化后的脂质概况
Takahiro Suzuki1,2, Sho Fukui3,4,5, Tomohiro Shinozaki6
1Department of Cardiovascular Medicine, St Luke's International Hospital, Tokyo, Japan.
JAMA network open
|March 12, 2025
概括
戒酒可能会使胆固醇水平恶化,低密度脂蛋白胆固醇 (LDL-C) 的增加更大,高密度脂蛋白胆固醇 (HDL-C) 的降低随着更重的戒酒而出现. 在减少酒精后监测脂质概况对于心血管健康至关重要.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 公共卫生 公共卫生
背景情况:
- 饮酒对健康的风险是有争议的,但它对脂质特征的影响,特别是在戒酒后,在密集干预之外并未得到充分理解.
- 了解酒精摄入量的变化如何影响胆固醇对于管理心血管疾病风险至关重要.
研究的目的:
- 调查酒精开始和戒酒之间的关联以及低密度脂蛋白胆固醇 (LDL-C) 和高密度脂蛋白胆固醇 (HDL-C) 的随后变化.
主要方法:
- 一项队列研究分析了日本东京 (2012-2022) 年度健康检查数据,不包括服用降脂药物的个人.
- 评估了来自57,691个人的数据,重点关注LDL-C和HDL-C在访问之间开始或停止饮酒后的LDL-C和HDL-C变化.
- 标准饮料定义为10g纯乙醇.
主要成果:
- 戒酒与增加的LDL-C和降低的HDL-C有关,并观察到剂量反应关系. 以往较高的酒精摄入量与戒酒后更显著的不良脂质变化相关.
- 开始饮酒时,与胆固醇水平有着适度的,反向的剂量反应关联.
- 例如,停止每天3个以上的饮料与6.53 mg/dL的LDL-C增加和5.65 mg/dL的HDL-C减少有关.
结论:
- 开始饮酒可能会带来适度的胆固醇益处,而戒酒则与不太有利的脂质状况有关.
- 这些发现强调了需要仔细监测酒精减少后的脂质变化,以优化心血管疾病风险管理.
- 公共卫生策略应该考虑这些脂质特征的变化与酒精消费模式的关系.
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