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多种omics通过子的肠-hypothalamic通信揭示了急性压力脆弱性

T Gu¹, R Guo¹, L Chen¹

¹State Key Laboratory for Quality and Safety of Agro-products, Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.

British poultry science

|March 12, 2025

概括

肠道微生物群通过改变下丘脑神经递质和微生物代谢来影响子的急性压力反应. 这项研究揭示了肠道细菌与大脑之间的联系.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
动物行为动物行为

背景情况:

鸟类肠道微生物组对于宿主功能至关重要.
在子中,肠道微生物群与下丘脑-垂体-上腺 (HPA) 轴在应激反应中的联系尚不清楚.

研究的目的:

研究肠道微生物群对子微生物代谢和宿主应激反应的影响.
为了比较下丘脑神经递质的可用性,微生物的组成,和共同代谢物在子与不同的压力避免行为.

主要方法:

较低的积极回避 (LAA) 和最高的积极回避 (HAA) 行为.
使用16S rRNA测序进行肠道微生物群分析.
在白内障和脑下垂体样本上进行了代谢分析.
进行了微生物和宿主代谢物之间的相关性分析.

主要成果:

在急性压力期间,HAA组显示了氨酸,氨酸,谷氨酸,上腺素,L-氨酸和黑激素的下丘脑可用性增加.
在易受压力影响的子和弹性子之间观察到肠道微生物群组成的显著差异.
代谢分析显示了改变的途径,包括cGMP-PKG信号传递,多巴胺突触和内分泌抵抗.

结论:

肠道微生物组在调节子急性压力反应方面发挥着重要作用.
鉴定出特定的共同代谢物,可能调解肠-海波他拉米轴通信.
提供了对肠-大脑轴影响鸟类行为和应激恢复能力的基础见解.

关键词:

16S rRNA 是一个16S rRNA.一个子,一个子,一个子.肠 - 甲状腺下垂体轴代谢组代谢组的代谢压力脆弱性压力脆弱性

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