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Updated: May 22, 2025

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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DNase TREX1是膜内蛋白酶SPP的基质,对疾病的发病有影响

Onur Kerem Tever1, Torben Mentrup1, Ivan Kingyue Chinn2

  • 1Institute for Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany.

Cellular and molecular life sciences : CMLS
|March 12, 2025
PubMed
概括

信号酸酶 (SPP) 分裂了DNA修复酶TREX1.1. 这一过程影响TREX1的稳定性和细胞质局部化,影响像艾卡迪-古提耶氏综合征这样的自身免疫性疾病.

关键词:
艾卡迪-古提耶尔综合征是什么?细胞质DNA降解细胞质DNA降解与ER相关的蛋白质降解.内膜蛋白质溶解是一种内膜蛋白质溶解.信号酸酶的信号酸.在cGAS/STING路径中.

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