睡眠不足增加中风风险:综合性发生率和死亡率元分析的证据
Zoltan Ungvari1,2,3,4,5, Mónika Fekete6, Andrea Lehoczki6,7
1Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
GeroScience
|March 12, 2025
概括
短时间和长时间的睡眠都会增加中风风险. 保持平衡的睡眠时间对于预防中风发病率和死亡率至关重要.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠时间和中风结果之间的关系尚未完全理解.
- 不正常的睡眠模式越来越被认为是潜在的健康风险.
研究的目的:
- 量化短时间和长时间睡眠对中风发病率和死亡率的影响.
- 研究睡眠时间与脑血管健康之间的关联.
主要方法:
- 进行了对队列研究的综合元分析.
- 分析了43项研究的数据,使用随机效应模型计算聚合危险比率 (HRs).
- 在主要的科学数据库中进行了搜索,截至2024年11月1日.
主要成果:
- 睡眠时间短 (≤5-6小时) 与中风发病率 (HR 1.29) 和死亡率 (HR 1.12) 的增加有关.
- 较长的睡眠时间 (>8-9小时) 与较高的中风发病率 (HR 1.46) 和死亡率 (HR 1.45) 有较强的关联.
- 观察到睡眠时间和中风风险之间存在U形的关联.
结论:
- 睡眠时间不足和过长都与中风风险增加有关.
- 均衡的睡眠时间是预防中风的关键可修改因素.
- 这些发现支持正在进行的塞梅尔维斯研究关于生活方式因素和脑血管衰老.
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