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Updated: May 22, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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通过基于GaMD轨迹的深度学习,了解化诱导对CDK6的构造和抑制剂结合的影响

Lu Zhao1, Jian Wang1, Wanchun Yang1

  • 1School of Science, Shandong Jiaotong University, Jinan 250357, China. zhaolusdu@163.com.

Physical chemistry chemical physics : PCCP
|March 12, 2025
PubMed
概括

化CDK6在T177显著改变其结构动态,特别是T循环,影响抑制剂结合. 这项研究揭示了开发新型CDK6抑制剂的关键分子机制.

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