咖啡因 - 克拉里思基因的同时使用和婴儿乳糖高血症:一个病例报告
Leila Costa Volpon1, Flavia Maria Costa1, Ana Paula de Carvalho Panzeri Carlotti1
1Division of Critical Care Medicine, Department of Pediatrics, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - São Paulo (SP), Brazil.
Critical care science
|March 12, 2025
概括
咖啡因和克拉里思罗米辛的同时使用可能会导致患有呼吸道感染的婴儿患有危险的乳酸化症. 在需要通风支持的幼儿中,应避免这种组合.
科学领域:
- 新生儿科学 新生儿科学
- 儿科药理学 儿科药理学
- 关键护理医学 关键护理医学
背景情况:
- 呼吸暂停是患有急性呼吸道感染的婴儿的严重并发症,通常需要呼吸系统支持.
- 咖啡因是治疗早产性呼吸暂停的标准治疗方法,但其对感染相关呼吸暂停的疗效仍有争议.
- 克拉里思罗米可以抑制药物代谢,高乳糖血是已知的咖啡因毒性风险.
研究的目的:
- 在早产婴儿中报告严重的高乳糖血症和代谢性酸症的病例,这是由于咖啡因和克拉里菌素的同时使用.
- 突出这种药物组合在脆弱儿科群体中的潜在风险.
主要方法:
- 一份病例报告详细介绍了一名早产婴儿患有急性呼吸道感染相关的呼吸暂停,需要非侵入性呼吸系统支持.
- 克拉里思罗米的给药,其次是咖啡因,随后对临床状态和血清乳酸盐水平进行监测.
- 停止服用这两种药物以评估高乳糖血症的消失.
主要成果:
- 婴儿最初在接受克拉里胺和咖啡因后,呼吸和呼吸暂停控制的改善.
- 尽管血液动力学稳定,但仍观察到血清乳酸盐度的逐渐增加和高离子间隙代谢酸性酸化.
- 血清乳酸水平在停止明素和咖啡因后正常化.
结论:
- 咖啡因 - 克拉里思罗米辛的同时使用可能会导致幼儿严重的高乳糖血症和代谢性酸症.
- 这种组合应非常谨慎地使用,并可能在患有急性呼吸道感染相关的呼吸道呼吸暂停的婴儿中避免使用.
- 需要进一步的研究来了解这种药物组合在新生儿中的药物动力学相互作用和临床影响.
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