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Updated: Jul 26, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
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从多能干细胞的二维培养中产生人类大脑器官的协议,绕过胚胎体聚合

Rosa González-Sastre1, Raquel Coronel2, Patricia Mateos-Martínez1

  • 1Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid 28220, Spain; Unidad de Biología Computacional, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid 28220, Spain; Doctoranda en la Escuela Internacional de Doctorado de la Universidad Nacional de Educación a Distancia (UNED), Programa en Ciencias Biomédicas y Salud Pública.

STAR protocols
|March 12, 2025
PubMed
概括

这项研究引入了一种新的协议,用于从二维多能干细胞 (PSC) 培养物中生成人类大脑器官 (hCOs). 这种方法绕过了细胞解离和胚胎体聚合,用于研究大脑发育和疾病.

关键词:
神经科学是一个神经科学.器官类动物 器官类动物干细胞是干细胞.

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相关概念视频

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Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...