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眼动脑神经病变和甲状腺癌的风险:一项韩国基于人口的研究

Jaeryung Kim¹, Kyung-Ah Park¹, Kyungdo Han²

¹Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

|March 12, 2025

概括

眼动脑神经病变 (OMCN) 可能预测甲状腺癌风险,特别是在糖尿病患者和妇女中. 这一发现强调了OMCN作为甲状腺癌的潜在早期指标.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

眼动脑神经病变 (OMCN) 与诸如肥胖,糖尿病 (DM),高血压和脂质失调等心血管风险因素有关.
OMCN与包括癌症在内的全身性疾病之间的潜在联系需要进一步调查.

研究的目的:

调查OMCN是否可以作为甲状腺癌发展的早期预测因素.
探索OMCN与随后的甲状腺癌诊断之间的关联,考虑心血管风险因素.

主要方法:

一个回顾性,全国性的,基于人口的队列研究,使用韩国国家医疗保险服务数据.
包括118,686名参与者 (≥20岁) 在2010-2017年间被诊断患有OMCN,与对照匹配.
使用危险比率 (HR) 和置信区间进行统计分析,并根据混因素进行调整.

主要成果:

患有OMCN的患者患上甲状腺癌的风险显著增加 (HR = 1.392).
这种关联在患有DM的参与者中 (HR = 2.288) 和女性中 (HR = 1.677) 更为明显.
对于基于性别的风险差异,观察到一个显著的p值 (p=0.0246).

结论:

OMCN可能是甲状腺癌风险的潜在早期预测因素,特别是在糖尿病患者和女性群体中.
建议进行进一步的研究,以阐明连接心血管风险因素,OMCN和甲状腺癌的潜在机制.
在OMCN患者中,主动管理心血管风险因素可能有助于预防甲状腺癌.

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