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在质子疗法中的实时剂量重建从内束PET测量结果

V V Onecha^1,2, A Espinosa-Rodriguez^1,2, C Soneira-Landín^1,2

¹Grupo de Física Nuclear, EMFTEL & IPARCOS, Universidad Complutense de Madrid, Madrid, Spain.

Physics in medicine and biology

|March 12, 2025

概括

在质子疗法 (PT) 中实时监测现在可以通过一个新的系统来实现,该系统可以重建3D剂量图,并使用内束正子发射断层扫描 (PET) 测量来验证质子范围.

科学领域:

医学物理医学物理
核医学就是核医学.
辐射瘤学辐射瘤学

背景情况:

临床质子疗法 (PT) 需要精确的剂量监测.
射线内射线正电子发射断层扫描 (PET) 提供了实时PT监控的潜力.
开发快速可靠的剂量计算引擎对于将PET整合到PT至关重要.

研究的目的:

实现3D剂量和活动图的实时重建.
用实验性内束PET测量来验证质子范围.
评估预测PT的范围转移的能力.

主要方法:

用70 MeV的质子束对PMMA幻影进行辐射.
使用了六模块PET扫描仪,具有在线重建功能.
集成基于GPU的3D重建算法与基于字典的软件,用于从PET活动中实时估计剂量.

主要成果:

精确的3D剂量图被重建并在一秒内显示.
检测到的范围偏移在8.4 Gy的剂量分数中只有1mm.
估计剂量降至1 Gy在线,在20秒获得后不确定度为<2 mm.

结论:

开发的硬件和软件可实现实时剂量映射和范围转移预测.
短的获取时间和小剂量足以进行准确的监测.
实时剂量重建和PT期间的监测是可行的,未来的工作重点是临床情景和PET原型升级.

关键词:

这就是IDE-PET的意义.在线活动重建在线活动重建在线剂量重建剂量重建在线范围验证在线范围验证质子剂量重建的重建质子疗法是一种质子疗法.

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