隐藏的信使:瘤微环境衍生出胃癌进展中的外体ceRNAs
Mohamed J Saadh1, Hanan Hassan Ahmed2, Radhwan Abdul Kareem3
1Faculty of Pharmacy, Middle East University, Amman 11831, Jordan.
Pathology, research and practice
|March 12, 2025
概括
瘤微环境 (TME) 衍生的外体RNA通过影响基因表达来调节胃癌 (GC) 的进展. 这些分子促进了诸如入侵和化学抵抗等特征,提供了潜在的诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 瘤微环境 (TME) 对胃癌 (GC) 的发展和进展至关重要.
- TME由癌细胞,免疫细胞,纤维细胞,内皮细胞和细胞外基质组成.
- 外基因组在TME中调解细胞间的通信.
研究的目的:
- 调查TME衍生的外体竞争性内源RNAs (ceRNAs) 在GC中的作用.
- 了解外体内非编码RNAs (lncRNAs) 和循环RNAs (circRNAs) 的长度如何调节GC.
- 突出外体ceRNAs作为GC诊断和治疗工具的潜力.
主要方法:
- 对TME,外体和胃癌中的ceRNAs现有文献的综述.
- 对外体ceRNAs影响TME内基因表达的机制的分析.
- 通过外体ceRNAs调节的关键癌症特征的识别,包括扩散,入侵,转移和化学抵抗.
主要成果:
- 外体ceRNAs,包括lncRNAs和circRNAs,在GC发育中起主要的调节作用.
- 这些分子通过控制TME组件的基因表达来放大癌症的标志.
- 外体ceRNAs通过免疫抑制,血管生成和上皮-介质细胞过渡 (EMT) 来促进瘤的发展.
结论:
- 外体ceRNAs修改TME以创建一个支持瘤的环境.
- 它们使癌细胞能够逃避免疫反应,抵抗细胞死亡,并适应治疗.
- 对GC中TME-外体ceRNA相互作用的进一步研究可能会产生新的诊断和治疗策略.
相关概念视频
The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Cancer Stem Cells and Tumor Maintenance
4.7K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.7K


