在中风患者中语言和非语言认知功能的异常静止状态神经活动和非语言认知功能障碍:一个横截面研究
Siqi Li1, Zinan Yuan1, Yuexiu Li2
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing 100070, China.
Clinical neurology and neurosurgery
|March 12, 2025
概括
脑卒中后失语症 (PSA) 患者表现出大脑活动和连接能力的改变,影响语言和非语言认知功能. 这些神经变化突显了语言和认知网络之间的重叠,为未来的康复策略提供了信息.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经学 神经学
背景情况:
- 在中风后失语症 (PSA) 中的语言障碍可以掩盖潜在的非语言认知缺陷.
- 在PSA中驱动语言和认知障碍的神经机制尚未完全理解.
研究的目的:
- 调查PSA患者的局部和远程大脑区域活动和功能异常.
- 探索这些神经变化与认知功能之间的关系,以改善临床治疗.
主要方法:
- 在46名PSA患者和40名对照人群中进行了横截面研究.
- 使用静止状态功能磁共振成像 (rs-fMRI) 来评估低频波动的分数幅度 (fALFF),区域同质性 (ReHo) 和功能连接性 (FC).
- 采用独立的两个样本t测试和部分相关性分析来比较小组,并确定大脑功能和认知表现之间的相关性.
主要成果:
- 在PSA患者中,右上小脑,左丘脑和左中额头环节的fALFF和ReHo减少,右上额头环节的活动增加.
- 左中额头和左下额头的轨道部分之间的CF降低与语言和非语言认知表现显著相关.
- 不流利的PSA患者表现出较差的认知功能和左丘脑和左补充运动区域之间的CF减少.
结论:
- 在PSA中,特定大脑区域的异常神经活动和功能连接对于语言和非语言认知功能至关重要.
- 在PSA中非语言认知衰退可能源于重叠的语言和认知神经网络.
- 未来的康复应该将语言和非语言功能整合到综合治疗计划中.
相关概念视频
01:10Higher Mental Functions of the Brain: Language
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
01:27Language and Cognition
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.