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Updated: May 22, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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通过PTPσ介导的PI3P调节调节了C9ORF72-ALS/FTD中神经退行

Zhe Zhang1, Xiujuan Fu1, Noelle Wright2

  • 1Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Neuron
|March 12, 2025
PubMed
概括

针对受体类型的氨酸蛋白酸酶S (PTPσ) 为C9ORF72相关的肌缩侧硬化症 (ALS) 和前性痴呆症 (FTD) 提供了一个有前途的治疗策略. 减少PTPσ通过恢复内分泌体功能来挽救神经退行.

关键词:
这就是ALS.C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C通过CRISPR查进行查.这是一个FTD.在PI3P中,PI3P是PI3P.这是PTPσσ.内分体内分体内分体内分体内分体内分体lysosome 溶解酶体是如何形成的聚-GR/PR 聚-GR/PR 的情况.

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