在发育过程中对空气污染暴露和大脑结构和功能进行系统审查
Jessica Morrel1, Michelle Dong2, Michael A Rosario3
1Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Environmental research
|March 12, 2025
概括
暴露于室外空气污染与儿童和青少年的大脑变化有关. 这份更新的综述强调了空气污染的新证据.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 空气污染物是影响大脑发育的已知的神经毒素.
- 之前的评论,包括2019年的一篇,已经探索了这一联系.
- 关于空气污染对年轻大脑的影响,新的证据正在出现.
研究的目的:
- 系统地审查有关户外空气污染暴露和儿童/青少年大脑结构和功能的最新证据.
- 评估自2019年审查以来的新磁共振成像 (MRI) 发现.
- 综合目前关于空气污染物对神经发育的影响的研究.
主要方法:
- 在PubMed,Web of Science和Scopus的系统文献搜索到2025年1月.
- 包括使用空气污染和功能/结构MRI关键词的研究.
- 独立的文章选和偏见风险评估.
主要成果:
- 确定了20项新研究,增加了2019年审查中的6项,共计26篇出版物.
- 研究涵盖了从怀孕到青春期的暴露,使用多样化的暴露评估和先进的MRI技术.
- 空气污染物与大脑差异有关,但研究结果不一致,限制了强有力的结论.
结论:
- 产前和儿童期暴露于室外空气污染与大脑结构和功能变异有关.
- 目前的文献包括纵向研究和先进的神经成像,超过了2019年审查的范围.
- 进一步的研究对于理解发育时间效应和长期认知/心理健康影响至关重要.
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