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Updated: May 9, 2026

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
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罗提古丁酸延长释放微球用于肌内注射的20周毒性研究在斯普拉格·道利大鼠中进行

Wenjing Lv1, Hong Zhang1, Yumeng Chen1

  • 1School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|March 12, 2025
PubMed
概括

在一项为期20周的老鼠毒性研究中,罗提古丁贝纳特延长释放微球 (RBEM) 显示出良好的安全差距. 这支持其在帕金森病的人类临床试验中的使用.

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相关概念视频

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...