奇托桑-酸微囊:一种提高牛乳酸稳定性和抗菌潜力的策略
Agustina Cots1, Nahuel Matías Camacho2, Santiago Daniel Palma2
1Instituto de Ciencias Veterinarias, Consejo Nacional de Investigaciones Científicas y Técnicas (INCIVET, CONICET), Universidad Nacional de Río Cuarto (UNRC), Río Cuarto 5800, Córdoba, Argentina.
International journal of biological macromolecules
|March 12, 2025
概括
奇托/阿尔金酸盐微粒保护口服乳酸免受胃部降解,增强其稳定性和对大肠杆菌的抗菌功效. 这种新的输送系统可以改善乳托费林.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输
- 微生物学 微生物学
背景情况:
- 口服乳酸显示出感染性疾病治疗的潜力,但由于胃部降解,其生物利用性较差.
- 提高乳费林的稳定性和输送对于其治疗应用至关重要.
研究的目的:
- 开发和描述用于口服Lactoferrin输送的奇托桑/阿尔金酸盐微粒.
- 为了评估这些微粒中封装的乳费林的稳定性,释放特征和抗菌活性.
主要方法:
- 通过外部离子凝合成的奇托/酸盐微粒.
- 使用FT-IR光谱,泽塔电位分析和在模拟胃肠道液体中的释放研究进行了表征.
- 针对大肠杆菌的抗菌分析.
主要成果:
- 微粒呈现出高的Lactoferrin加载效率 (93.65%) 和小尺寸.
- 封装的乳酸显示在模拟的胃和肠液中稳定性提高.
- 奇托桑/阿尔金酸盐微囊保留了拉克托费林对大肠杆菌的抗菌活性.
- 作用机制涉及通过LPS相互作用破坏细菌膜的稳定.
结论:
- 奇托/阿尔金酸盐微粒是口服乳酸输送的有希望的策略.
- 这种系统增强了乳酸的稳定性,生物可用性和治疗潜力.
- 进一步的研究可以探索这个系统的其他治疗蛋白质.
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