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相关概念视频

Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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相关实验视频

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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快速可分离的泡微针贴片系统呈现出优越的透皮mRNA传递效率.

Jiayu Wu1, Jun Zuo2, Wei Dou1

  • 1Department of Pharmacy & State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China; Bioinformatics Center of AMMS, Beijing, People's Republic of China.

International journal of pharmaceutics
|March 12, 2025
PubMed
概括

这项研究引入了一种新的气泡微针贴片,用于室温稳定的mRNA疫苗. 这种通过皮肤输送系统提高了mRNA疫苗的稳定性和可访问性,为传统注射提供了最少侵入性的替代方案.

关键词:
可以溶解的微针.脂质纳米颗粒是一种纳米粒子.这就是SARS-CoV-2病毒.这是mRNA疫苗.

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科学领域:

  • 生物技术是生物技术.
  • 材料科学 材料科学 材料科学
  • 免疫学 免疫学 免疫学

背景情况:

  • 在脂质纳米颗粒 (mRNA-LNP) 中的传统mRNA疫苗面临着冷保存需求,痛苦的注射和肝脏聚合等挑战.
  • 可溶性微针 (DMN) 提供最少的侵入性透皮输送,但在固化过程中与mRNA-LNP不稳定性作斗争.

研究的目的:

  • 开发一种快速溶解的气泡微针贴片 (bMNP) 系统,用于稳定地通过皮肤输送mRNA-LNP.
  • 为了提高mRNA-LNP在室温下的稳定性,并使向淋巴结的输送.

主要方法:

  • 使用聚乙烯醇 (PVA) 和三糖作为基质材料制备微针.
  • 开发一个气泡微针贴片 (bMNP) 带有气泡用于背部分离.
  • 使用编码SARS-CoV-2尖端蛋白的mRNA进行体内评估.

主要成果:

  • 改善了mRNA-LNP稳定性,允许在室温下储存超过一个月.
  • 经过证明的背部尺度分离和有效的 in vivo 淋巴结向.
  • 诱导显著的高峰特异性IgG抗体,中和抗体和Th1极化T细胞反应.

结论:

  • 气泡微针贴片 (bMNP) 系统为mRNA疫苗提供了一个稳定,可在室温下储存和有效的透皮输送平台.
  • 这一战略为mRNA输送提供了一个有希望的替代途径,有可能改善疫苗的可访问性和患者的遵守性.