黑兰种子油 - 化学成分,抗氧化剂/抗微生物活性和体外伤口愈合潜力
Nemanja Krgović1, Dejan Stojković2, Marija Ivanov2
1Institute for Medicinal Plants Research "Dr. Josif Pančić", 11000 Belgrade, Serbia.
Fitoterapia
|March 12, 2025
概括
来自塞尔维亚的黑兰种子油富含烯酸和α-烯酸,具有显著的抗氧化和抗菌特性. 它还表现出强大的体外伤口愈合能力,没有细胞毒性.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 黑兰种子油 (Rubus occidentalis L.) 是一种具有潜在健康益处的天然产品.
- 了解其详细的化学成分和生物活性对于其应用至关重要.
研究的目的:
- 为了描述塞尔维亚黑兰种子油的化学特征.
- 为了评估其抗氧化,抗微生物和体外伤口愈合潜力.
主要方法:
- 气相色谱-质谱 (GC/MS) 用于脂肪酸分析.
- 高性能液体染色学 (HPLC) 用于托科尔组成.
- 对胡卜素,抗氧化活性 (DPPH,ABTS,FRAP) 的光谱测定.
- 对抗菌和抗真菌活性进行微生物学测定.
- 在体外测试 (细胞活力,划伤测试) 用于HaCaT细胞的伤口愈合.
主要成果:
- 主要的脂肪酸: 烯酸 (39.30%), α-烯酸 (30.49%), 油脂 (18.94%).
- 主要的多科菲醇: γ-多科菲醇 (166.80毫克/100克);总胡卜素: 1.20毫克/100克.
- 强有力的抗氧化活性 (DPPH IC50: 3.02 毫克/毫升,ABTS IC50: 1.33 毫克/毫升,FRAP: 393.74 μmol Fe2+/100 g).
- 对沙门氏菌Typhimurium,大肠杆菌,大肠杆菌,B. cereus具有显著的抗菌活性,对阿斯伯吉卢斯和Trichoderma具有抗真菌活性.
- 在HaCaT细胞上没有细胞毒性 (IC50>401μg/mL).
- 在100μg/mL度的HaCaT细胞中,增强了伤口愈合的2.41倍.
结论:
- 塞尔维亚黑兰种子油具有丰富的脂肪酸和托科尔特.
- 它表现出显著的抗氧化,抗微生物和体外伤口愈合特性.
- 油是健康应用的有希望的候选者,特别是在伤口管理中.
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