相关实验视频

Updated: May 22, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

胸部疾病中的非编码RNA:巴雷特食道和食道腺癌

Siyuan Sheng¹, Jianhui Guo², Chuangang Lu³

¹Department of Medicine, Hunan University of Arts and Science, Changde, Hunan Province 415000, China.

Clinica chimica acta; international journal of clinical chemistry

|March 12, 2025

概括

非编码RNAs (ncRNAs) 是从巴雷特食道 (BE) 发生食道腺癌 (EAC) 的关键调节者. 这些分子为早期EAC检测和新的治疗点提供了有希望的非侵入性生物标志物.

科学领域:

分子瘤学分子瘤学
胃肠病学胃肠病学
生物标志物发现发现

背景情况:

食道腺癌 (EAC) 是一种具有不良预后的侵袭性癌症,通常是由巴雷特食道 (BE) 引起的,这是一种与GERD相关的癌前状况.
从BE向EAC的进展涉及复杂的分子变化,需要改进早期检测和治疗策略.
非编码RNAs (ncRNAs) 越来越多地被认为是它们在癌症发展中的调节作用.

研究的目的:

审查ncRNAs在从BE到EAC的进展中的参与.
探索ncRNAs作为EAC的治疗标和非侵入性生物标记物的潜力.
讨论基于ncRNA的策略对EAC的临床翻译挑战和未来前景.

主要方法:

文献综述侧重于微RNAs,长非编码RNAs和循环RNAs在BE和EAC中的作用.
在食道癌发生过程中通过ncRNAs调节的信号通路 (例如,Wnt/β-catenin,NF-κB) 的分析.
评估ncRNAs在生物流体中的稳定性,以发现潜在的生物标志物.

主要成果:

ncRNAs显著影响基因表达和细胞过程,这些过程对EAC发育至关重要.
特定的ncRNA参与调节关键的瘤信号通路.
ncRNAs在生物流体中表现出稳定性,这表明它们可以作为非侵入性生物标志物.

结论:

ncRNAs在EAC的发病过程中发挥着关键作用,从BE进展到恶性瘤.
在EAC中,ncRNAs代表了早期检测生物标志物和向治疗的有希望的候选人.
需要进行进一步的研究,以克服将ncRNA发现转化为EAC管理的临床应用的挑战.

关键词:

巴雷特的食道.消化道腺癌消化道腺癌没有编码的RNAs.

更多相关视频

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Barrett Esophagus-II: Clinical Manifestations and Management

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

RNA Splicing

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...