在荷兰初级医疗保健中,夸提阿平处方的模式和适用情况
Busra R Cinar1, Suzanne A Ligthart2, Hugo Ajm de Wit1
1Department of clinical pharmacy, Canisius Wilhelmina Hospital, Utrecht University, Utrecht, The Netherlands.
BJGP open
|March 12, 2025
概括
在荷兰,针对睡眠问题的非标签提的处方正在增加. 尽管有警告,这种趋势仍然存在,这凸显了对其原因和后果的进一步研究的需要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 奎蒂阿平已批准用于治疗精神分裂症,双相情感障碍和严重抑郁症.
- 它的镇静作用导致非标签用于失眠,尽管潜在的副作用.
- 全球越来越多的奎提阿平使用需要对处方模式进行分析.
研究的目的:
- 为了调查荷兰初级医疗保健中奎蒂亚平的处方趋势.
- 具体检查非标签使用奎胺的程度和原因.
主要方法:
- 荷兰 (2003-2022) 国家和区域处方数据的回顾性分析.
- 对抗精神病趋势的检查和按剂量详细的奎平模式的检查.
- 从患者记录中分析处方指示,包括自由文本数据.
主要成果:
- 总体而言,抗精神病药物的使用增加了,这是由于提处方增加了13倍的原因.
- 在区域范围内,奎蒂亚平的使用量增加了3.3倍 (2012-2021年),特别是在较低剂量 (<100毫克/天) 时.
- 在2020-2022年,76.6%的新使用奎胺的患者有非标签的症状,46.9%的患者有睡眠问题.
结论:
- 在荷兰,非标签的奎提阿平处方,特别是用于睡眠问题,正在增加.
- 尽管存在临床指南和警告,但这种趋势仍在发生.
- 进一步调查这种处方做法的驱动因素和长期影响是有必要的.
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