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Updated: May 22, 2025

Single-Molecule Analysis of Sf9 Purified Superprocessive Kinesin-3 Family Motors
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Published on: July 27, 2022

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计算机建模揭示了基因素-1和图布林C-终端尾巴之间的捕捉指导相互作用

Trini Nguyen1, Steven P Gross2,3, Christopher E Miles1,4

  • 1Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.

Traffic (Copenhagen, Denmark)
|March 12, 2025
PubMed
概括

素运动蛋白沿微管道运输细胞载荷. 这项研究揭示了蛋白C端尾 (CTTs) 如何指导激素-1运动,影响细胞内运输,这对细胞健康和疾病至关重要.

关键词:
计算建模计算建模细胞骨架 细胞骨架在中国,中国就是中国.微管是微管的组成部分.管道中的管道.

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Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
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Microtubules are the thickest cytoskeletal filaments with a diameter of 25 nm. In prokaryotic organisms, microtubules are commonly found in locomotory appendages like cilia and flagella. In eukaryotic cells, microtubules form specialized extensions for moving fluid over the surface, like those found in cells lining the intestine.
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Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
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